Aburi Girls' Senior High School, previously known as Aburi Girls' Secondary School and affectionately referred to as ABUGISS, stands as a cornerstone of education in the Eastern Region of Ghana.

Adonten Senior High School, situated south of Aburi in Ghana's Eastern Region, is a prominent coeducational first-cycle institution offering a diverse range of academic programs.

St. Rose's Senior High School, commonly known as Rosec or Roses, is a public Catholic high school for girls located in Akwatia, in Ghana's Eastern Region. Established in 1965 by the Dominican Sisters, the school has become a well-known institution in the region.

Pope John Senior High School and Minor Seminary, commonly known as POJOSS, is an all-boys boarding school located in Effiduase, Koforidua, in Ghana's Eastern Region. Established in 1958 by Bishop Joseph Oliver Bowers SVD.

St. Peter's Senior High School, commonly known as PERSCO, is a prominent Roman Catholic boys' senior high school located in Nkwatia Kwahu on the Kwahu Ridge in the Eastern Region of Ghana.