Saint Thomas Aquinas Senior High School, located in the Osu district of Accra within the Greater Accra Region of Ghana, stands as a centre of educational opportunity for boys in the region. Established in 1952, the school was founded by Catholic missionaries.

Presbyterian Boys' Secondary School (PRESEC) is a renowned secondary boarding school for boys located in Legon, Accra, Ghana. Founded in 1938 under the auspices of the Presbyterian Church of the Gold Coast.

Achimota School commonly known as Motown, is a co-educational public boarding high school situated in Achimota, Accra, in the Greater Accra Region of Ghana.

O'Reilly Senior High School, commonly known as

Christian Methodist Senior High School, a co-educational public secondary institution located in New Aplaku within the Ga South Municipality of the Greater Accra Region.

Chemu Secondary School, located in Community Four of Tema in the Greater Accra Region of Ghana, is a coeducational day-boarding institution with no provision for hostel facilities.

Labone Senior High School, popularly known as L-A Bone, is a public senior high school situated in Labone, within the Greater Accra Region of Ghana.

St. Mary's Senior High School, located in Korle Gonno in the Greater Accra Region of Ghana, is an all-female second-cycle institution.

Accra Girls Senior High School, situated in Accra within the Greater Accra Region of Ghana, stands as a prominent all-female second-cycle institution.

Accra Academy, a prestigious boys' high school located at Bubuashie near Kaneshie in the Greater Accra Region of Ghana, admits both boarding and day students. Founded in 1931 as a private school, it gained Government-Assisted School status in 1950.